Activity based probe analysis

Details Activity based probe analysis Activity based probe analysis

2006-08-01

2006-08-01

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

C436S086000, C436S172000, C436S800000, C530S402000, C536S026100

Reexamination Certificate

active

07083987

ABSTRACT:
Methods and compositions are described for analyzing complex protein mixtures using fluorescent activity-based probes. In particular, probes that specifically react with and bind to the active form of one or more target proteins are employed. Fluorescent signals obtained from the labeled active target proteins can be related to the presence or amount of active members of the desired target protein class. The methods and compositions described herein can be used, for example, to provide diagnostic information concerning pathogenic states, in identifying proteins that may act as therapeutic targets, and in drug discovery.

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