Active variants of FGF with improved specificity

Details Active variants of FGF with improved specificity Active variants of FGF with improved specificity

2007-10-30

2007-10-30

Saoud, Christine J. (Department: 1647)

Chemistry: molecular biology and microbiology

Vector, per se

C514S002600, C514S012200, C536S023400, C536S023500, C530S350000, C530S399000

Reexamination Certificate

active

10424955

ABSTRACT:
The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.

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