Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1996-12-23
1999-06-15
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
A61K 3112
Patent
active
059122722
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION
The present invention relates particularly to active compounds and formulations for treatment of senile xerosis.
Senile xerosis is caused, for example, by endogenous, genetically determined factors. In the epidermis and dermis, for example, the following age-related structural damage and dysfunctions which fall under the term "senile xerosis" occur: itching (pruritus) and/or reduced re-oiling by sebaceous glands (for example after washing).
Exogenous factors, such as UV light and chemical noxae, can have a cumulative effect and, for example, accelerate or supplement the endogenous ageing processes. In the epidermis and dermis, for example, the following structural damage and dysfunctions which go beyond the extent and quality of the damage during chronological ageing and senile xerosis occur, in particular, in the skin due to exogenous factors: senile keratosis) and
The present invention particularly relates to active compounds and products for treatment of the secondary damage of skin ageing and senile xerosis, in particular the phenomena listed under a) to e).
Products for the care of aged skin are known per se. They comprise, for example, retinoids (vitamin A acid and/or derivatives thereof) or vitamin A and/or derivatives thereof. However, the extent of their action on the structural damage is limited. Furthermore, in product development, there are considerable difficulties in stabilizing the active compounds adequately against oxidative decay. The use of products comprising vitamin A acid moreover often causes severe erythematous skin irritations. Retinoids can therefore be employed only in low concentrations.
Cosmetic formulations with coenzyme Q-10 which are suitable for treatment of skin diseases, for prophylaxis of dystrophic and dysmetabolic states of the skin and for use in cases of chemical and physical respiratory damage or delayed respiration associated with age and wear are furthermore known from DE-A-33 09 850.
Japanese Laid-Open Specification 58,180,410 describes the suitability of coenzyme Q-10 for cosmetics. It is said to activate skin cell metabolism and suppress oxidation. As a result, coenzyme Q-10 has an important function in the prevention of skin damage due to UV rays and the prevention of ageing of the skin. In 20- to 40-year olds, the roughness of the skin is improved by the skin being given moisture.
The object of the present invention was thus to discover ways of avoiding the disadvantages of the prior art. In particular, the effect of eliminating the damage associated with senile xerosis and exogenous ageing of the skin is to be permanent, lasting and without the risk of side effects.
These objects are achieved by the invention.
The invention relates to the use of topical formulations having a content of one or more compounds from the group consisting of ubiquinones and derivatives thereof for treatment of senile xerosis and/or exogenous ageing of the skin.
The topical formulations according to the invention can be cosmetic or dermatological formulations.
The invention also relates to the use of one or more compounds from the group consisting of ubiquinones and derivatives thereof for treatment of senile xerosis and/or exogenous ageing of the skin.
It has been found, surprisingly, that ubiquinones and derivatives thereof not only protect the skin from damage due to chronological ageing of the skin, in particular ageing due to light, but also bring about the repair of damage already caused to the skin by senile xerosis and exogenous ageing of the skin, which significantly remedies the disadvantages of the prior art. The action of this group of substances on structural changes in senile skin is particularly advantageous.
"Ubiquinones" here also means "ubiquinones and derivatives thereof".
During senile xerosis, in particular, the following age-related structural damage and dysfunctions occur: re-oiling by sebaceous glands (for example after washing).
During exogenous ageing of the skin, which is caused, for example, by UV light and chemical noxae, the following dysf
REFERENCES:
patent: 5378461 (1995-01-01), Neigut
Patent Abstracts of Japan, vol. 8, No. 11(C-205), 1984.
Hoppe Udo
Sauermann Gerhard
Schreiner Volker
Steiger Klaus-Michael
Beiersdorf AG
Henley III Raymond
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