Active site modified protease .alpha.-1-antitrypsin inhibitors

Details Active site modified protease .alpha.-1-antitrypsin inhibitors Active site modified protease .alpha.-1-antitrypsin inhibitors

1984-06-14

1988-03-22

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1300

Patent

active

047329734

ABSTRACT:
Proteinaceous composition are provided which inhibit naturally occurring serine proteases. Particularly, an amino acid sequence analogous to human .alpha..sub.1 -antitrypsin is modified at the active site while maintaining protease inhibition. The methionine at the active site is substituted with an oxidatively stable amino acid, while other amino acids may also be changed, added or deleted, particularly at the termini.
The yeast strains AB103.1 (pCl/PH05ATi(Val) and AB110 (pCl/1GAPATi(Val) were deposited at the A.T.C.C. on June 18, 1984 and given Accession Nos. 20711 and 20712, respectively.

REFERENCES:
Archives of Biochem. & Biophys. 188 (1978), 226-227.
The Journal of Biol. Chem. 254, 4022-4026 (1979).
PCT/WO86/00337, 16 Jan. 1986 Courtney.
The Journal of Biological Chem. 255, (1980), 3931-3934.
Angew Chem. Int. Ed. Engl. 20, (1981), 295-296.
Archives of Biochemistry & Biophys. 177, 552-560 (1976).
Biochim. et Biophys. Acta. 453 (1976), 257-261.

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