Active site labelling of plasminogen

Details Active site labelling of plasminogen Active site labelling of plasminogen

1990-08-06

1993-02-16

Rollins, John W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 771, 436 69, 424 9464, C12Q 156, C12Q 100, G01N 3386

Patent

active

051870690

ABSTRACT:
A plasminogen, which has a label incorporated into an active site thereof such that said plasminogen is enzymatically and catalytically inactive upon its conversion to plasmin, and an enzymatically and catalytically inactive plasmin with a label incorporated into an active site thereof.
A method of making a labelled plasminogen which is enzymatically and catalytically inactive upon conversion to plasmin is provided along with an assay method which utilizes a labelled plasminogen.

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patent: 4808405 (1989-02-01), Smith et al.
Paul E. Bock, "Active Site Selective . . . Arg-CH.sub.2 Cl", American Chemical Society, 1988; reprinted from Biochemistry, 1988, 27, 6633.
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Cell Biology: Structure, Biochemistry and Function, Sheeki et al. (1980).
Thrombosis Res. vol. 34, No. 5, Lijnen et al. (1984).
Blood vol. 76, No. 4, Mann et al. (1990).

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