Active-site engineering of nucleotidylyltransferases and...

Combinatorial chemistry technology: method – library – apparatus – Library – per se – Library containing only organic compounds

Reexamination Certificate

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C435S193000

Reexamination Certificate

active

07906460

ABSTRACT:
The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Epor other nucleotidyltransferases; and nucleotide sugars synthesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

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