Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-01-11
1998-08-04
Lilling, Herbert J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
426430, 426542, 426544, 426655, A61K 3578, A23L 1303
Patent
active
057889716
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to active oxygen free radical scavenging agent for scavenging active oxygen free radicals produced in the process of metabolizing in organisms.
BACKGROUND ART
Active oxygen free radicals produced in organisms are known to attack nucleic acid, protein, nucleotide, amino acid, sugar, organic acid, etc. They are also known to have significant relationships to inflammation, cerebral hemorrhage, arterial sclerosis, generation of cancers, destroying or weakening of cancers, radiation damage, cataract, aging, etc.
For scavenging such active oxygen free radicals, rhubarb, i.e. Chinese GAOU is effective as an active oxygen free radical scavenging agent according to "Free Radicals and Medicines in Japan and China" published by KOKUSAI ISHO SHUPPAN. Catechin extracted from green tea leaves also has an effect to scavenge active oxygen free radicals according to "Fragrance J." published by Fragrance Journal.
Those conventionally developed active oxygen free radical scavenging agents could not perfectly prevent generation of cancers, etc., for they were not effective enough to scavenge active oxygen free radicals produced in organisms.
DISCLOSURE OF INVENTION
Wherefore, an object of this invention is to provide an active oxygen free radical scavenging agent for scavenging active oxygen free radicals produced in organisms effectively.
To attain this object, the present invention provides an active oxygen free radical scavenging agent including green tea leaf extract containing epigallo catechin gallate and sunflower seed extract containing chlorogenic acid.
As a result of measuring active oxygen free radical scavenging effects with various chemical products, the applicant discovered that sunflower seed extract has an effect to scavenge active oxygen free radicals.
Furthermore, the measurement revealed that the active oxygen free radical scavenging effect when administrating green tea leaf extract containing epigallo catechin gallate and sunflower seed extract simultaneously greatly excels the same when the two kinds of extracts are separately administrated.
The active oxygen free radical scavenging agent according to the present invention effectively scavenges active oxygen free radicals, for it includes green tea leaf extract containing epigallo catechin gallate and sunflower seed extract containing chlorogenic acid.
The mixing amounts of green tea leaf extract and sunflower seed extract are, for example when these extracts are dispersed in water, both preferably from 0.01 weight per cent to 10.00 weight per cent. In addition, antioxidants such as ascorbic acid, vitamin E and beta carotene, and fragrances, etc., may be included in the agent.
For dispersing the above extracts, substances such as xanthum gum, Guar gum, carboxymethyl cellulose, saponin, fatty acid esters and soybean protein are added and dispersed with the conventional type of homogenizer.
When manufacturing the agent in solid or powdered form, the amounts of each extracts are selected at will. As being dispersed in water, antioxidants such as ascorbic acid, vitamin E and beta carotene, fragrances, etc., may be included. Various methods such as mixing with lactose, dextrin, food material, etc. before dispersing is applicable.
BRIEF DESCRIPTION OF DRAWINGS
FIG. 1 is a graphs which shows the effect of the active oxygen free radical scavenging agent embodying the present invention.
BEST MODE FOR CARRYING OUT THE INVENTION
The embodiment of the invention is now explained referring to the drawing FIGURE.
In an organism seized with renal failure, active oxygen free radical, mentioned free radical hereafter, especially hydroxyradical, acts to produce methylguanidine from creatine existing in muscles of vertebrates. Therefore, according to "Free Radicals and Medicines in Japan and China" published by KOKUSAI ISHO SHUPPAN, a research shows that by measuring the amount of methylguanidine in urine of animals seized with renal failure, the amount of hydroxyradical existing in the organism is estimated.
Based on the a
REFERENCES:
patent: 4387110 (1983-06-01), Emmi et al.
"Free Radicals and Medicines in Japan and China" by Kokusai Isho Shuppan.
Lilling Herbert J.
Sky. Food Co., Ltd.
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