Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-09-26
1993-08-03
Cashion, Jr., Merrell C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
5483631, 5483711, 548375, 548376, 5483681, C07D23100
Patent
active
052330443
ABSTRACT:
Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.
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G. Losse et al., Leibigs Ann. Chem., 684:236-242 (1968) [Translated from German].
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B. Castro et al., In: Peptides: Proceedings of the European Peptide Symposium, pp. 79-84, A. Loffet (ed.), Editions Univ. Bruxelles, Brussels, Belgium (1976).
Cashion Jr. Merrell C.
Celsa Bennett
Millipore Corporation
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