Active ester used for production of acylated amino acids

Details Active ester used for production of acylated amino acids Active ester used for production of acylated amino acids

1989-06-20

1993-06-01

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Chemical aftertreatment, e.g., acylation, methylation, etc.

530335, 530336, 560114, 562561, 558271, A61K 3702, C07L 6736

Patent

active

052161250

ABSTRACT:
A process for producing an amide or an ester represented by the general formula W-A-B-Y which involves reacting an ester sulfonium salt represented by the general formula: ##STR1## with a nucleophilic agent represented by the general formula

REFERENCES:
patent: 4126628 (1978-11-01), Paquet
patent: 4857656 (1989-08-01), Kouge
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K. Kouge et al. "Peptide Synthesis in Aqueous Solution. I. Application of P-Dialkyl-sulfoniophenols as a Water-Soluble Coupling Reagent" Bull Chem. Soc. Japan, 60,2409-2418 (1989).
Morrison & Boyd, Organic Chemistry 3rd Ed. (Ally & Bacon) 1979 pp. 32-34; 660-675; 755-756.
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