Active derivatives of methylamino in therapeutic compositions an

Details Active derivatives of methylamino in therapeutic compositions an Active derivatives of methylamino in therapeutic compositions an

1975-08-22

1977-09-13

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2605011, 260583H, 260583J, 260583R, A61K 3113

Patent

active

040483347

ABSTRACT:
Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.tbd.CH--R.sub.4 or an alkynyl radical of the formula C=C--R.sub.4, in which R.sub.4 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.1, R.sub.2 and R.sub.3 being such that no compound of formula I possesses more than 13 carbon atoms.
They are useful for treating Parkinson's disease and for correcting extra-pyramidal disturbances provoked by neuroleptics.

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patent: 3413278 (1968-11-01), Weinrich et al.
patent: 3574760 (1971-04-01), Sasaki et al.
patent: 3644525 (1972-02-01), Thiele
Vejdelek et al., "Collection Czechoslov Chem. Commun.," vol. 35, pp. 2810-2811 and 2814 (1970).

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