Active compound release systems

Details Active compound release systems Active compound release systems

1984-12-14

1987-04-28

Lieberman, Allan M.

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

424 78, 424 83, 428156, 604897, A61F 702, A61F 1302, A61L 1503, A61L 1506

Patent

active

046611045

ABSTRACT:
In a therapeutic system such as a plaster for administration of an active compound through the skin and comprising a covering layer which is essentially impermeable to the active compound, an active compound reservoir layer and a protective layer which can be pulled off and which is essentially impermeable to the active compound, the improvement wherein the reservoir layer contain about 1-30% of active compound in an elastomer mixture comprising a predominantly amorphous olefinic (co)polymer with a glass transition temperature of <20.degree. C., mixed with from 0 up to about 50% by weight of a polyisobutylene, polybutadiene oil and/or paraffin oil, and a tackifying resin. Thereby the active compound can be released in regulated relatively large quantity over a prolonged period of time.

REFERENCES:
patent: 3742951 (1973-07-01), Zafforoni
patent: 3996934 (1976-12-01), Zafforoni
patent: 4031894 (1977-06-01), Urquhart et al.
patent: 4201211 (1980-05-01), Chandrasekoran et al.
patent: 4420407 (1983-12-01), Otsuka et al.
patent: 4455146 (1984-06-01), Noda et al.

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