Active CMOS biosensor chip for fluorescent-based detection

Optics: measuring and testing – Plural test

Reexamination Certificate

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C356S317000, C356S318000, C436S172000, C435S004000, C435S006120

Reexamination Certificate

active

07738086

ABSTRACT:
An active CMOS biosensor chip for fluorescent-based detection is provided that enables time-gated, time-resolved fluorescence spectroscopy. In one embodiment, analytes are loaded with fluorophores that are bound to probe molecules immobilized on the surface of the chip. Photodiodes and other circuitry in the chip are used to measure the fluorescent intensity of the fluorophore at different times. These measurements are then averaged to generate a representation of the transient fluorescent decay response unique to the fluorophores. In addition to its low-cost, compact form, the biosensor chip provides capabilities beyond those of macroscopic instrumentation by enabling time-gated operation for background rejection, easing requirements on optical filters, and by characterizing fluorescence lifetime, allowing for a more detailed characterization of fluorophore labels and their environment. The biosensor chip can be used for a variety of applications including biological, medical, in-the-field applications, and fluorescent lifetime imaging applications.

REFERENCES:
patent: 5039219 (1991-08-01), James et al.
patent: 5812272 (1998-09-01), King et al.
patent: 6078705 (2000-06-01), Neuschafer et al.
patent: 6117643 (2000-09-01), Simpson et al.
patent: 6197503 (2001-03-01), Vo-Dinh et al.
patent: 6317207 (2001-11-01), French et al.
patent: 6331438 (2001-12-01), Aylott et al.
patent: 6448064 (2002-09-01), Vo-Dinh et al.
patent: 6469785 (2002-10-01), Duveneck et al.
patent: 6743581 (2004-06-01), Vo-Dinh
patent: 6784982 (2004-08-01), Blumenfeld et al.
patent: 6803238 (2004-10-01), Eggers
patent: 6867851 (2005-03-01), Blumenfeld et al.
patent: 6975251 (2005-12-01), Pavicic
patent: 7145645 (2006-12-01), Blumenfeld et al.
patent: 7179654 (2007-02-01), Verdonk et al.
patent: 2003/0143575 (2003-07-01), Caria
patent: 2004/0175821 (2004-09-01), Ehman
patent: 2004/0234417 (2004-11-01), Schienle et al.
patent: 2004/0249227 (2004-12-01), Klapproth et al.
patent: 2005/0136448 (2005-06-01), Hartel et al.
patent: 2006/0014151 (2006-01-01), Ogura et al.
patent: 2006/0134644 (2006-06-01), Hartel et al.
patent: 2006/0197960 (2006-09-01), Bazylenko
patent: 2007/0121111 (2007-05-01), Blumenfeld et al.
patent: 2008/0265177 (2008-10-01), Connally et al.
Schena, M. et al., “Microarrays: biotechnology's discovery platform for functional genomics,” Trends in Biotechnology, vol. 16, pp. 301-306, Jul. 1998.
Daubert, S.J. et al., “Current Copier Cells,” Electronic Letters, vol. 24, No. 25, pp. 1560-1562, Dec. 8, 1988.
Mir, K.U. et al., “Sequence Variation in Genes and Genomic DNA: Methods for Large-Scale Analysis,” Annu. Rev. Genomics Hum, Genet. 2000. 1:329-60.
McIntosh, S.L., et al., “Fluorescence Lifetime for On-the-Fly Multiple Detection of DNA Restriction Fragments in Capillary Electrophoresis,” Analytical Chemistry, vol. 72, No. 1, pp. 5444-5449, Nov. 1, 2000.
Templin, M.T. et al., “Protein microarray technology,” Trends in Biotechnology, vol. 20, No. 4, pp. 160-166, Apr. 2002.
Daubert, S.J. et al., “A Transistor-Only Current-Mode ΣΔ Modulator,” IEEE Journal of Solid-State Circuits, vol. 27, No. 5, pp. 821-830, May 1992.
Hacia, J.G. et al., “Mutational analysis using oligonucleotide microarrays,” J. Med. Genet, pp. 730-736, 1999.
Hyun, D. et al., “Limit Cycles and Pattern Noise in Single-Stage Single-Bit Delta-Sigma Modulators,” IEEE Transactions on Circuits and Systems—I: Fundamental Theory and Applications, vol. 49, No. 5, pp. 646-656, May 2002.
Eltoukhy, H. et al., “A 0.18 μm CMOS 10-5Iux Bioluminescence Detection System-on-Chip,” ISSCC 2004 / Session 12 / Biomicrosystems / 12.3, pp. 1-3.

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