Active carbonates of polyalkylene oxides for modification of pol

Details Active carbonates of polyalkylene oxides for modification of pol Active carbonates of polyalkylene oxides for modification of pol

1992-01-08

1994-06-28

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435177, 435188, 530363, 5303891, 530406, 530410, 546208, 546243, 548435, 548465, 548475, 548542, C07D20746, C07D21194, C07D40312

Patent

active

053248449

ABSTRACT:
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.

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Matsuda, et al. Chem Abstracts 1989; 111;112046m.

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