Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-02-17
1997-03-18
Tsang, Cecilia
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530345, 530402, 530409, 530410, 548520, 548465, 548475, 548542, 4241931, 4241941, 435 681, 435177, 435181, 435188, C07K 1600, C07D20740, A61K 39385, C12P 2106
Patent
active
056124600
ABSTRACT:
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.
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Enzon Inc.
Mercanti Michael N.
Mohamed Abdel A.
Tsang Cecilia
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