Active carbonates of polyalkylene oxides for modification of pol

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530345, 530402, 530409, 530410, 548520, 548465, 548475, 548542, 4241931, 4241941, 435 681, 435177, 435181, 435188, C07K 1600, C07D20740, A61K 39385, C12P 2106

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056124600

ABSTRACT:
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.

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