Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1983-05-26
1986-01-14
Williams, Howard S.
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
604896, 604304, 604307, 604308, A61F 1500
Patent
active
045643644
ABSTRACT:
The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater than saturation. The depleted zone is disposed between the surface through which the agent is to be dispensed and at least a substantial portion of the non-depleted zone with the interface therebetween disposed at a non-uniform distance from the releasing surface. Certain embodiments are particularly useful for the transdermal administration of drugs.
REFERENCES:
patent: 3342183 (1967-09-01), Edenbaum
patent: 3598127 (1971-08-01), Wepsic
patent: 3854480 (1974-12-01), Zaffaroni
patent: 3921636 (1975-11-01), Zaffaroni
patent: 3923939 (1975-12-01), Baker et al.
patent: 3926188 (1975-12-01), Baker et al.
patent: 3948262 (1976-04-01), Zaffaroni
patent: 3993072 (1976-11-01), Zaffaroni
patent: 4024871 (1977-05-01), Stephenson
patent: 4031894 (1977-06-01), Urguhart et al.
patent: 4057619 (1977-11-01), Higuchi et al.
patent: 4201211 (1980-05-01), Chandrasekoran et al.
patent: 4286592 (1981-09-01), Chandrasekoran
patent: 4292965 (1981-10-01), Nash et al.
Higuchi, J. Pharm. Sci., vol. 50, No. 10 (Oct., 1961), pp. 874-875.
Higuchi, J. Pharm. Sci., vol. 52, No. 12 (Dec., 1963), pp. 1145-1149.
Chien et al., J. Pharm. Sci., vol. 63, No. 4 (Apr., 1974), pp. 515-519.
Wong Patrick S.-L.
Zaffaroni Alejandro
ALZA Corporation
Mandell Edward L.
Sabatine Paul L.
Stone Steven F.
Williams Howard S.
LandOfFree
Active agent dispenser does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Active agent dispenser, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Active agent dispenser will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-429009