Active agent containing hydrogel devices wherein the active agen

Details Active agent containing hydrogel devices wherein the active agen Active agent containing hydrogel devices wherein the active agen

1986-06-02

1988-06-07

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424 81, A61K 926, A61K 3174

Patent

active

047495766

ABSTRACT:
An active agent containing controlled release diffusion device comprising a swellable hydrogel matrix in the non-swollen state, interpenetrated with an active agent solute having a stable concentration distribution increasing in a gradient normal to the surface of the device and between the surface and the core thereof, said gradient being in the form of a substantially continuous, inflection point containing, sigmoidal curve, such that the device, when placed in an aqueous hydrogel swelling environment, release said active agent in a controlled continuous manner by diffusion for a predetermined period of time, a method of preparing such a device, and the use thereof to release an active agent into the intended environment of use.

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