Activators of peroxisome proliferator-activated receptors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S866000

Reexamination Certificate

active

07547730

ABSTRACT:
Activators of peroxisome proliferator-activated receptors comprising a polyprenyl compound, preferably (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, as an active ingredient, and medicaments for preventive and/or therapeutic treatment of hyperlipidemia, non-insulin dependent diabetes mellitus or the like comprising a polyprenyl compound as an active ingredient.

REFERENCES:
patent: 4346109 (1982-08-01), Yamatsu et al.
patent: 4491592 (1985-01-01), Katoh et al.
patent: 4655973 (1987-04-01), Yamatsu et al.
patent: 4757140 (1988-07-01), DeLuca et al.
patent: 4788330 (1988-11-01), Nakamoto et al.
patent: 4841038 (1989-06-01), DeLuca et al.
patent: 4883916 (1989-11-01), Nakamoto et al.
patent: 4888439 (1989-12-01), Yamatsu et al.
patent: 4917829 (1990-04-01), Yamatsu et al.
patent: 5852057 (1998-12-01), Muto et al.
patent: 6369251 (2002-04-01), Takano et al.
patent: 6984742 (2006-01-01), Tanikawa et al.
patent: 2005/0250671 (2005-11-01), Shidoji et al.
patent: 2006/0094784 (2006-05-01), Kagawa et al.
patent: 781809 (1957-08-01), None
patent: 054732 (1982-06-01), None
patent: 0107188 (1984-05-01), None
patent: 194693 (1986-09-01), None
patent: 0847754 (1998-06-01), None
patent: 1046630 (2003-03-01), None
patent: 2073750 (1981-10-01), None
patent: 54-046821 (1979-04-01), None
patent: 55-22645 (1980-02-01), None
patent: 55-138457 (1980-10-01), None
patent: 58-109415 (1983-06-01), None
patent: 62-77317 (1987-04-01), None
patent: 63-32058 (1988-06-01), None
patent: 6332058 (1988-06-01), None
patent: 63-166824 (1988-07-01), None
patent: 6334855 (1988-07-01), None
patent: 10-167960 (1998-06-01), None
patent: 2000 122974 (2000-04-01), None
patent: 94/22818 (1994-10-01), None
patent: 01/15702 (2001-03-01), None
patent: 01/80854 (2001-11-01), None
patent: 03/097034 (2003-11-01), None
patent: 2004/017958 (2004-03-01), None
U.S. Appl. No. 10/524,420, to Reiko Kawamura et al., filed Aug. 19, 2003.
Nariaki Nakamura et al., “Apoptosis in Human Hepatoma Cell Line Induced by 4,5-Didehydrogeranylgeranoic Acid (Acyclic Retinoid) Via Down-Regulation of Transforming Growth Factor-α,” Biochemical and Biophysical Research Communications, vol. 219, No. 1, pp. 100-104 (1996).
M. Okuno et al., “Retinoids Exacerbate Rat Liver Fibrosis by Inducing the Activation of latent TGF-β in Liver Stellate Cells,” Hepatology (Philadelphia), vol. 26, No. 4, pp. 913-921 (1997).
Di Bisceglie A.M. et al., “Hepatocellular Carcinoma,” Hepatology, vol. 28, No. 4, pp. 1161-1165 (1998).
Ishiwari, K., “The Effects of a Synthetic Retinoid on Phenotypic Expression of Cultured Mesangial Cells,” Kyoto-furitsu Ika Daigaku Zasshi, vol. 106, No. 3, pp. 273-283 (1997).
English language Abstract of JP 56-140949.
English language Abstract of JP 10-167960.
English language Abstract of JP 54-046821.
English language Abstract of JP 55-22645.
English language Abstract of JP 58-109415.
English language Abstract of JP62-77317.
English language Abstract of JP63-166824.
Yasutoshi Muto, et al., “Prevention of Second Primary Tumors by an Acyclic Retinoid in Patients with Hepatocellular Carcinoma” New Eng. J. Med., vol. 340, No. 13, pp. 1046-1047 (1999).
K. Tago et al., “A Practical Total Synthesis of Plaunotol via Highly Z-selective Wittig Olefination of α-acetal ketones,” J. Chem. Soc. Perkin Trans. 1, pp. 2073-2078 (2000).
W.C. Still et al., “Direct Synthesis of Z-Unsaturated Esters. A Useful Modification of the Horner-Emmons Olefination,” Tetrahedron Letters, vol. 24, No. 41, pp. 4405-4408 (1983).
T. Kajiwara et al., “Steroselective Synthesis of Ectocarpene and Its Antipode via Microbiological Asymmetric Hydrolysis,” Agric. Biol. Chem., vol. 45, pp. 1461-1466 (1981).
Chinese Journal of Applied Chemistry, vol. 5, 1988, pp. 70-71.
R. Boden, “A Mild Method for Preparing trans-Alkenes; Crown Ether Catalysis of the Wittig Reaction,” Synthesis, p. 784 (1975).
G. Bellucci et al., “Crown Ether Catalyzed Stereospecific Synthesis of Z- and E-Stilbenes by Wittig Reaction in a Solid-Liquid Two-Phases System,” Tetrahedron Letters, vol. 37, No. 24, pp. 4225-4228 (1996).
M. Mikolajczyk et al., “Synthesis of α,β-Unsaturated Sulphides, Sulphoxides, and Sulphones by the Horner-Wittig Reaction in Two-Phase System Catalysed by Quaternary Ammonium Salts and Crown Ethers,” Synthesis, pp. 278-280 (1975).
Izv. Akad. Nauk SSSR, Khim., 1990, pp. 2544-2550.
Izv. Akad. Nauk SSSR, Khim., 1988, pp. 2382-2385.
Izv. Akad. Nauk SSSR, Khim., 1988, pp. 2377-2382.
R.N. Gedye et al., “The Stereochemistry of the Wittig Reactions of Allylic Phosphroranes and Phosponate Esters with Aldehydes,” Can. J. Chem., vol. 55, pp. 1218-1228 (1977).
K. Ashizawa et al., “The Crystal Structure of 3,7,11,15-Tetramethyl-2,4,6,10,14- All Trans-Hexadecapentaenoic Acid (E-5166),” Chem. Pharm. Bull., vol. 33, No. 7, pp. 3062-3064 (1985).
English Language Abstract of JP 57-106638 corresponding to JP Appln. No. 63-34855.
English Language Abstract of JP 56-140949 corresponding to JP Appln. No. 63-32058.
Reaven, G.M., Diabetes, vol. 37, pp. 1595-1607 (1988).
Issemann, I., et al., Nature, vol. 347, pp. 645-650, 1990.
Lehmann, J.M., et al., J. Biol. Chem. vol. 270, pp. 12953-12956, 1995.
Saltiel, A.R., et al., Diabetes, vol. 45, pp. 1661-1669, 1996.
Rinshu Iyaku., et al., vol. 14, pp. 461-466, 1998.
Muto, Y., et al., N. Eng. J. Med., 334,pp. 1561-1567, 1996.
Davis, J.B., et al., J. Chem. Soc (C), pp. 2154-2165, 1966.
Ellinghaus, P., et al., J. Biol. Chem., vol. 274, No. 5, pp. 2766-2772 (1999).
Kliewer, S.A., et al., Proc. Natl. Acad. Sci. U.S.A., vol. 94, No. 9, pp. 4318-4323 (1997).
Göttlicher, M., et al., Biochem. Pharmacol., vol. 46, No. 12, pp. 2177-2184 (1993).
Issemann, I., et al., J. Mol. Endocrinol., vol. 11, No. 1, pp. 37-47 (1993).
Remngton: The Science and Practice of Pharmacy, Mack Publishing Co., Nineteenth Edition , vol. 1(1995), Chapter 48, “The Introduction of New Drugs”, pp. 795-808.
Http://www.truestarthealth.com /Notes/1028005.htm (2007) High Cholesterol.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Activators of peroxisome proliferator-activated receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Activators of peroxisome proliferator-activated receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Activators of peroxisome proliferator-activated receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4131003

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.