Activators of cyclin-dependent kinases

Details Activators of cyclin-dependent kinases Activators of cyclin-dependent kinases

2006-04-25

2006-04-25

Monshipouri, Maryam (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S320100, C536S023200

Reexamination Certificate

active

07033816

ABSTRACT:
A new gene family involved in cell cycle regulation was discovered. This family has been termed activators of cyclin-dependent kinases (ACDKs). A number of ACDK genes have been cloned and sequenced. Proteins encoded by ACDK genes specifically were shown to interact with CDKs and pRb, and to upregulate the kinase activity of a CDK using pRb as a substrate. Progression of a cell through the cell cycle can be regulated by modulating ACDK expression in the cell.

REFERENCES:
Databank on Genbank, Accession No. Q9JIM7, Wang et al., “Characterization of mACPD1, mACDP2, mACDP3 and mACDP4, the mouse homologs of human ACDO gene family,” Oct. 01, 2000.
Database on Genbank, Accession No. AF169226, Wang et al., “Identification of ACDP1—a member of a new gene family and its exclusion as a candidate for the Urofacial (ochoa) Syndrome (UFS) on chromosome 10q23-10q24,” Jul. 19, 2000.
Database on Genbank, Accession No. AF216962, Wang et al., “Identification of novel gene family (ACDP) conserved for C. elegans to human, molecular characterization of ACDP2, ACDP3 and ACDP4,” Jul. 19, 2000.
Database on Genbank, Accession No. AF216965, Wang et al., “Identification of novel gene family (ACDP) conserved for C. elegans to human, molecular characterization of ACDP2, ACDP3 and ACDP4,” Jul. 19, 2000.
Database on Genbank, Accession No. AF202777, Wang et al., “Identification of a novel gene family (ACDP) conserved for C. elegans to human, molecular characterization of ACDP2, ACDP3, and ACDP4,” Jul. 19, 2000.
Database on Genbank, Accession No. AF202994, Wang et al., “Characterization on mACPD1, mACDP2, mACDP3 and mACDP4, the mouse homologs of the human gene family,” Jul. 19, 2000.
Databank on Genbank, Accession No. AF216961, Wang et al., “Characterization of mACDP1, mACDP2, mACDP3 and mACDP4, the mouse homologs of the human ACDP gene family”, Jul. 19, 2000.
Databank Genbank, Accession No. AF 216963, Wang et al., “Characterization of mACDP1, mACDP1, mACDP2, mACDP3 and mACDP4, the mouse homolog of the human gene family,” Jul. 19, 2000.

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