Activator gene for macrolide biosynthesis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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536 237, 536 241, 935 78, C12Q 168, C07H 2104

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active

055145442

ABSTRACT:
A gene encoding activator protein (srmR) for increasing transcriptional efficiency of macrolide biosynthetic genes is disclosed and claimed. Methods for using srmR to increase macrolide biosynthetic gene transcription and identifying further macrolide biosynthetic pathways are disclosed. Recombinant DNA vectors comprising the srmR gene are disclosed.

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Hutchinson, C. Richard, et al. (1989) Journal of Medicinal Chemistry 32:929-937.
Hopwood, D. A., (1989) Phil Trans. R. Soc. Lond. B324:549-562.

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