Activation-state-specific phosphoprotein immunodetection

Details Activation-state-specific phosphoprotein immunodetection Activation-state-specific phosphoprotein immunodetection

1994-10-13

1997-02-04

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 74, 436547, 436548, 436543, 5303877, 5303879, 5303888, 53038885, 5303897, G01N 3353, G01N 33574

Patent

active

055996817

ABSTRACT:
Activation-state-specific and protein-specific antiphosphoprotein antibodies and methods for their production are disclosed. Also disclosed are methods for evaluating the prognosis and therapeutic outcome for patients using the antiphosphoprotein antibodies and methods for characterizing the activation state of a reversibly phosphorylated protein, kits including the antibodies for use in characterizing the activation state of a protein, and methods for evaluating the agonist or antagonist activity of pharmaceutically useful compounds towards the conversion of a specific protein from its inactive to its active state.

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