Activation of peptide prodrugs by hK2

Details Activation of peptide prodrugs by hK2 Activation of peptide prodrugs by hK2

2011-03-15

2011-03-15

Audet, Maury (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S329000, C424S001690

Reexamination Certificate

active

07906477

ABSTRACT:
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodrug by hK2, the therapeutic drugs are activated and exert their toxicity. Methods for treating cell proliferative disorders are also featured in the invention.

REFERENCES:
patent: 2008/0247950 (2008-10-01), Denmeade et al.

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