Activation of macrophage tumoricidal activity by granulocyte-mac

Details Activation of macrophage tumoricidal activity by granulocyte-mac Activation of macrophage tumoricidal activity by granulocyte-mac

1986-07-31

1992-01-07

Kepplinger, Esther L.

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 8, 514 21, 424 858, 424 93, 435 695, 4351722, 4351723, 530350, 530351, 530387, 530828, A61K 4505, A61K 3766

Patent

active

050789961

ABSTRACT:
Macrophages and precursor monocytes are activated to exhibit tumoricidal activity by stimulation solely with granulocyte-macrophage colony stimulating factor. A patient suffering from tumors can be treated by direct administration of therapeutically effective quantities of activated granulocyte-macrophage colony stimulating factor. Homogeneous granulocyte-macrophage colony stimulating factor for use in activating macrophages and monocyte precursors is prepared by recombinant DNA techniques. The gene coding for granylocyte-macrophage colony stimulating factor is isolated and then recombinant protein product expressed in an appropriate expression system. The granulocyte-macrophage colony stimulating factor recovered from the expression system is purified to homogeneity by reverse phase high-performance liquid chromatography.

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