Activation of herpes simplex virus protease by kosmotropes

Details Activation of herpes simplex virus protease by kosmotropes Activation of herpes simplex virus protease by kosmotropes

1995-04-06

1997-04-08

Kight, John

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 18, 435 24, 435 34, 435 5, 435 4, 435 29, 4352351, 530300, 530328, 530329, C12Q 137, C12Q 134, C12Q 102, A61K 3800

Patent

active

056186851

ABSTRACT:
Native Herpes Simplex Virus type 1 (HSV type 1) protease has a rather low activity. It has been found however, that the presence of a kosmotropic anion can increase the activity of the protease over 10-fold. This has many advantages, as now assays for protease activity may be run in very small (micromolar and less) amounts of reagents and substrates, and the assays can be run quickly. Activate HSV-1 protease represents a conformational change from native protease.

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Darke, P.L. et al. Activation of the Herpes Simplex Virus - 1 Protease, 1994, pp. 1-20.

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