Activation of HCV-specific T cells

Details Activation of HCV-specific T cells Activation of HCV-specific T cells

2007-10-23

2007-10-23

Campbell, Bruce R. (Department: 1648)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S228100, C424S189100, C424S169100

Reexamination Certificate

active

10357619

ABSTRACT:
The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4+and CD8+T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a,and NS5bpolypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of these fusions. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.

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