Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-02
1998-06-30
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 149, 424 934, 424 94, 435 724, 436 86, 436 87, 5303887, 5303896, A61K 5100, C07K 1628, G01N 3350
Patent
active
057732280
ABSTRACT:
The present invention provides a thrombin-activated platelet protein (TAPP). The protein is selectively expressed on the surface of thrombin-activated platelets. Antibodies which selectively bind to the thrombin-activated platelet protein are also provided. These compositions find use in the detection and treatment of blood clots.
REFERENCES:
patent: 4783330 (1988-11-01), Furie et al.
patent: 4820505 (1989-04-01), Ginsberg et al.
patent: 5256538 (1993-10-01), Aiken et al.
Bennett, Joel S., "The Molecular Biology of Platelet Membrane Proteins", Seminars in Hematology 27(2):186-204 (Apr. 1990).
Bode, Christoph et al., "Antibody-Directed Urokinase: A Specific Fibrinolytic Agent", Science 229:765-767 (Aug. 23, 1985).
Febbraio, Maria et al., "Identification and Characterization of LAMP-1 as an Activation-dependent Platelet Surface Glycoprotein", J. Biol. Chem. 265(30):18531-18537 (Oct. 25, 1990).
Frelinger III, Andrew L. et al., "Selective Inhibition of Integrin Function by Antibodies Specific for Ligand-occupied Receptor Conformers", J. Biol. Chem. 265(11):6346-6352 (Apr. 15, 1990).
Gerrard, J.M. et al., "Identification of a Platelet Dense Granule Membrane Protein That Is Deficient in a Patient with the Hermansky-Pudlak Syndrome", Blood 77(1):101-112 (Jan. 1, 1991).
Gogstad, Geir O. et al., "Platelet Factor XIII Is an Active Enzyme After Solubilization and Crossed Immunoelectrophoresis", Thrombosis Research 29(2):237-241 (1983).
Gralnick, H.R. et al., "A Monoclonal Antibody which Recognizes a New Activation Dependent Antigen and Results in the Enhanced Binding of Fibrinogen to Activated Platelets", Blood 76(Suppl.1):457A, Abstract No. 1818 (1990).
Hayward, Catherine P.M. et al., "p-155, A Multimeric Platelet Protein That Is Expressed on Activated Platelets", J. Biol. Chem. 266(11):7114-7120 (Apr. 15, 1991).
Hayward, Catherine P.M. et al., "P-155: A Novel, Multimeric Platelet Protein That Is Released With Platelet Activation and Expressed on the Surface of Activated Platelets", Blood 76(Suppl.1):458A, Abstract No. 1824 (1990).
Hsu-Lin, Shu-Chun et al., "A Platelet Membrane Protein Expressed during Platelet Activation and Secretion", J. Biol. Chem. 259(14):9121-9126 (Jul. 25, 1984).
Johnston, Geoffrey I. et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation", Cell 56:1033-1044 (Mar. 24, 1989).
Larsen, Eric et al., "PADGEM Protein: A Receptor That Mediates the Interaction of Activated Platelets with Neutrophils and Monocytes", Cell 59:305-312 (Oct. 20, 1989).
McEver, Rodger et al., "A Monoclonal Antibody to a Membrane Glycoprotein Binds Only to Activated Platelets", J. Biol. Chem. 259(15):9799-9804 (Aug. 10, 1984).
Morrison, Sherie L., "Transfectomas Provide Novel Chimeric Antibodies", Science 229:1202-1207 (Sep. 20, 1985).
Nieuwenhuis, H. Karel et al., "Studies With a Monoclonal Antibody Against Activated Platelets: Evidence That a Secreted 53,000-Molecular Weight Lysosome-like Granule Protein Is Exposed on the Surface of Activated Platelets in the Circulation", Blood 70(3):838-845 (Sep. 1987).
Savage, Brian et al., "Thrombin-Induced Increase in Surface Expression of Epitopes on Platelet Membrane Glycoprotein IIb/IIIa Complex and GMP-140 Is a Function of Platelet Age", Blood 74(3):1007-1014 (Aug. 15, 1989).
Sutherland, D. Robert et al., "Identification of a Cell-Surface Antigen Associated with Activated T Lymphoblasts and Activated Platelets", Blood 77(1):84-93 (Jan. 1, 1991).
Matsueda Gary R.
Reed Guy L.
Saunders David
The General Hospital Corporation
LandOfFree
Activation-dependent protein expressed on the surface of activat does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Activation-dependent protein expressed on the surface of activat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Activation-dependent protein expressed on the surface of activat will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1857625