Activation compounds and methods of synthesis of activation comp

Details Activation compounds and methods of synthesis of activation comp Activation compounds and methods of synthesis of activation comp

1989-10-26

1992-08-18

Yarbrough, Amelia Burgess

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 435810, 436501, 514455, 514457, 536 27, 935 78, 935 88, C12Q 168

Patent

active

051399407

ABSTRACT:
The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4169204 (1979-09-01), Hearst et al.
patent: 4196281 (1980-04-01), Hearst et al.
patent: 4312883 (1982-01-01), Baccicetti et al.
patent: 4398031 (1983-08-01), Bender et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
National Institutes of Health, Federal Register 41:27902 (1976).
National Institutes of Health, Federal Register 43:60108 (1978).
E. Fisher and D. R. Lincoln, Recomb. DNA Tech. Bull. 7:1 (1984).
R. W. Old and S. B. Primrose, Principles of Gene Manipulatoin, pp. 157-158 (Univ. of Cal, Press, 2nd Edition 1981).
T. Maniatis et al., Molecular Cloning, pp. 23-24 (Cold Spring Harbor Laboratory 1982).
P. M. Lizardi et al., Biotechnology 6:1197 (1988).
D. L. Kacian et al., Proc. Natl. Acad. Sci. USA 69:3038 (1972).
B. C. F. Chu et al., Nucleic Acids Res. 14:5591 (1986).
P. Knight, Biotechnology 7:609 (1989).
S. Kwok and R. Higuchi, Nature 339:237 (1989).
PCR Technology, H. A. Erlich (ed.) (Stockton Press 1989).
K. Mullis et al., Cold Spring Harbor Symposia, vol. LI, pp. 263-273 (1986).
G. D. Cimino et al., Ann. Rev. Biochem. 54:1151 (1985).
J. E. Hearst et al., Quart. Rev. Biophys. 17:1 (1984).
S. T. Isaacs et al., Biochemistry 16:1058 (1977).
S. T. Isaacs et al., Trends in Photobiology (Plenum) pp. 279-294 (1982).
J. W. Tessman et al., Biochem. 24:1669 (1985).
F. Bordin et al., Experentia 35:1567 (1979).
F. Dall'Acqua et al., Medeline Biologie Envir. 9:303 (1981).
S. Caffieri et al., Medecine Biologie Envir. 11:386 (1983).
F. Dall'Acqua et al., Photochem Photobio. 37:373 (1983).
G. Guiotto et al., Eur. J. Med. Chem-Chim. Ther. 16:489 (1981).
F. Dall'Acqua et al., J. Med. Chem. 24:178 (1984).
S. Isaacs et al., Nat. Cancer Inst. Monograph No. 66:21 (1985).
Green et al., Biochem. J. 125:781 (1971).
J. P. Albarella et al., Nucleic Acids Res. 17:4293 (1983).
L. Bretherick, Hazards in the Chemical Laboratory (Royal Society, London 1981) (p. 247).
D. R. Bender et al., J. Org. Chem. 44:2176 (1979).
N. D. Heindel et al., J. Hetero. Chem. 22:73 (1985).
Hyde and Hearst, Biochemistry 17:1251 (1978).
Thompson et al., J. Mol. Biol. 147:417 (1981).
Thompson et al., Biochemistry 21:1363 (1982).
W. I. Wood et al., Proc. Natl. Acad. Sci. 82:1585 (1985).
Guiotto et al., J. Med. Chem. 27:959 (1984).
I. Willis and J. M. Menter, Nat. Cancer Inst. Monograph 66:143 (1985).
P. R. Langer et al., Proc. Natl. Acad. Sci. U.S.A. 78:6633 (1981).
P. D. Moore et al., Proc. Natl. Acad. Sci 78:110 (1981).
P. D. Moore et al., Proc. Natl. Acad. Sci. 79:7166 (1982).
J. G. Piette and P. D. Moore, Photochem. Photobiol. 35:705 (1982).
C. N. Ou et al., Biochemistry 17:1047 (1978).
J. G. Piette and J. E. Hearst, Proc. Natl. Acad. Sci. 80:5540 (1983).
J. G. Piette and J. E. Hearst, Int. J. Radiat. Biol. 48:381 (1985).
G. Ericson and P. Wollenzien, Analytical Biochem. 174:215 (1988).
M. Chamberlin et al., Nature 228:227 (1970).
D. Y. Wu and R. B. Wallace, Genomics 4:560 (1989).
G. J. Murakawa et al., DNA 7:287 (1988).
G. D. Cimino et al., Biochemistry 25:3013 (1986).
C. Y. Ou et al., Science 239:295 (1988).
Bordin et al., Z. Naturforsch. 33:296 (1978).
Bordin et al., Photochem. Photobiol. 29:1063 (1979).

Affiliated with

Also associated with

Rating

Activation compounds and methods of synthesis of activation comp does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Activation compounds and methods of synthesis of activation comp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Activation compounds and methods of synthesis of activation comp will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1248620