Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-05-11
1989-11-21
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530300, 530351, 530388, 530403, 530806, 435 68, 4352402, 424 851, 424 858, 424 88, 935104, 935108, A61K 39395, A61K 3900, C12P 2100
Patent
active
048824240
ABSTRACT:
An essentially purified antigen comprising a protein present in the T-cells of Aotus trivirgatus having molecular weights of 140 KD and 105 KD under reducing conditions and 120 KD and 90 KD under non-reducing conditions, antibodies against this antigen, and a method of using these antibodies to activate T-cells. The antibodies are able to induce T-cell activation in synergy with phorbol myristate acetate alone and with antibody against the T 11.sub.3 epitope of T 11 (CD.sub.2) antigen alone.
REFERENCES:
patent: 4363799 (1982-12-01), Kung et al.
patent: 4364937 (1982-12-01), Kung et al.
patent: 4401756 (1983-08-01), Gillis
patent: 4550086 (1986-10-01), Reinherz et al.
patent: 4596774 (1986-06-01), Chang et al.
patent: 4613458 (1986-09-01), Okai
patent: 4623622 (1986-11-01), Anderson
patent: 4636463 (1987-01-01), Altman et al.
patent: 4683199 (1987-07-01), Palladino
Hoxie et al., The Journal of Immunology (Baltimore, Md., U.S.A.) vol. 137, No. 4, Issued Aug. 15, 1986, "Transient Modulation and Internalization of T4 Antigen Induced by Phorbol Esters", pp. 1194-1201.
Jan L. Ceuppens et al., "Monoclonal Antibodies to the CD5 Antigen Can Provide the Necessary Second Signal for Activation of Isolated Resting T Cells by Solid-Phase-Bound OKT3", Journal of Immunology, vol. 137, No. 6, Sept. 15, 1987, 1816-1821.
Soo Young Yang et al., "A Common Pathway for T Lymphocyte Activation Involving Both The CD3-Ti Complex and CD2 Sheep Erythrocyte Receptor Determinants", Journal of Immunology, vol. 137, No. 4, Aug. 15, 1986, 1097-1100.
Stefan C. Meuer et al., "An Alternative Pathway of T-Cell Activation" Cell, vol. 36, Apr. 1984, 897-906.
Ellis L. Reinherz et al., "The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones", Immunological Review, vol. 74, 1983, 83-112.
Alessandro Moretta et al., "Involvement of T44 Molecules In an Antigen Independent Pathway of T Cell Activation", Journal of Experimental Medicine, vol. 162, Aug. 1985, 823-838.
Toshiro Hara et al., "Human T Cell Activation", Journal of Experimental Medicine, vol. 161, Jun. 1985, 1513-1524.
Paul J. Martin et al., "Identification and Functional Characterization of Two Distinct Epitopes on the Human T Cell Surface Protein Tp50", Journal of Immunology, vol. 131, No. 1, Jul. 1983, 180-185.
Ronald Palacios et al., "Is the E Receptor on Human T Lymphocytes A `Negative Signal Receptor`"? Journal of Immunology, vol. 129, No. 6, Dec. 1982, 2479-2593.
Morimoto Chikao
Rudd Christopher
Schlossman Stuart
Dana-Farber Cancer Institute Inc.
Mohamed Abdel A.
Moskowitz Margaret
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