Activated protein C formulations

Details Activated protein C formulations Activated protein C formulations

1998-04-24

2000-12-12

Weber, Jon P.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 3848

Patent

active

061594687

ABSTRACT:
The present invention relates to pharmaceutical formulations of activated protein C which also comprises sucrose, sodium chloride and sodium citrate buffer at a pH between about 5.5 and about 6.5. The activated protein C formulations of the present invention are more stable than other formulations of activated protein C and demonstrate fewer degradation products over time.

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Grinnell, et al., "Trans-Activated Expression of Fully Gamma-Carboxylated Recombinant Human Protein C, An Antithrombotic Factor", Bio/Technology, 5:1189-1192, 1987.

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