Activated polyoxazolines and compositions comprising the same

Details Activated polyoxazolines and compositions comprising the same Activated polyoxazolines and compositions comprising the same

2011-05-17

2011-05-17

Wu, David (Department: 1762)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

C424S078080, C424S078360, C424S078380, C424S178100, C424S179100, C424S193100, C424S280100, C525S410000, C525S411000, C525S417000, C525S540000, C528S403000, C528S417000, C528S422000, C528S423000

Reexamination Certificate

active

07943141

ABSTRACT:
The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.

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