Activated polymers and conjugates thereof

Details Activated polymers and conjugates thereof Activated polymers and conjugates thereof

1990-08-24

1992-02-25

Raymond, Richard L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

530545, 530402, 530403, 530405, 530391, 536 22, 580 32, 580 33, 580 34, 580 50, 564 50, 564 51, 564149, 564158, 564159, 564271, 564443, A61K 3702, A61K 3900

Patent

active

050909142

ABSTRACT:
Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## in which R.sup.1 is H, C.sub.1 -C.sub.20 alkyl, phenyl, (C.sub.1 -C.sub.10 alkyl)-substituted phenyl, or phenyl-substituted C.sub.1 -C.sub.10 alkyl; R.sup.2 is C.sub.2 -C.sub.5 alkylene or (C.sub.1 -C.sub.4 alkoxy)-substituted C.sub.2 -C.sub.5 alkylene; R.sup.3 is ##STR2## R.sup.4 is H or C.sub.1 -C.sub.4 alkyl; n is at least 5; and m is zero or 1.

REFERENCES:
patent: 2714608 (1955-08-01), Matter
patent: 4179337 (1979-12-01), Davis et al.
patent: 4515981 (1985-05-01), Otani et al.
Buckmann et al., "Functionalization of Poly(ethylene glycol) and Monomethoxy-Poly(ethylene glycol)", Makromol Chem., 182, 1385-1390 (1981).
Ouchi et al., "Enzyme and Nonenzyme Hydrolyses of End Ester Group in Polyethylene Glycol Esters", J. Macromol. Sci.-Chem., A21(5), 583-591 (1984).
Abuchowski et al., "Cancer Therapy with Chemically Modified Enzymes . . . ", Cancer Biochem. Biophys., vol. 7, 175-186 (1984).
Abuchowski et al., "Alteration of Immunological Properties . . . ", J. Bio. Chem., vol. 262, No. 11, 3578-3581 (1977).
Abuchowski et al., "Effect of Covalent Attachment of Polyethylene Glycol . . . ", J. Bio. Chem., vol. 252, No. 11, 3582-3586 (1977).
Savoca et al., "Induction of Tolerance in Mice by Uricase . . . ", Int. Archs. Allergy appl. Immun., 75, 58-67 (1984).
Kamisaki et al., "Reduction in Immunogenicity and Clearance Rate . . . ", J. Phar. Exper. Ther., vol. 216, 410-414 (1981).
Shih et al., "Modification of Immunotoxins for Improved Cancer Therapy", Proceedings of AACR, vol. 28, 1987.
Ferruti et al., "Succinic Half-esters of Poly(ethylene glycols)s . . . ", Makromol. Chem. 182, 2183-2192 (1981).
Abuchowski et al., "Soluble Polymer-Enzyme Adducts," 367-383.

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