Activated polymers and conjugates thereof

Details Activated polymers and conjugates thereof Activated polymers and conjugates thereof

1992-07-15

1993-06-22

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 50, 564 51, 564149, 564159, 564163, 528 69, 435181, C07C21574

Patent

active

052217710

ABSTRACT:
Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## in which R.sup.1 is H, C.sub.1 -C.sub.20 alkyl, phenyl, (C.sub.1 -C.sub.10 alkyl)-substituted phenyl, or phenyl-substituted C.sub.1 -C.sub.10 alkyl; R.sup.2 is C.sub.2 -C.sub.5 alkylene or (C.sub.1 -C.sub.4 alkoxy)-substituted C.sub.2 -C.sub.5 alkylene; R.sup.3 is ##STR2## R.sup.4 is H or C.sub.1 -C.sub.4 alkyl; n is at least 5; and m is zero or 1.

REFERENCES:
patent: 4448729 (1984-05-01), Klaubert et al.
patent: 4683333 (1987-07-01), Britt et al.
patent: 5091582 (1992-02-01), Sanders et al.

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