Activated polyethylene glycol compounds

Details Activated polyethylene glycol compounds Activated polyethylene glycol compounds

2006-08-01

2006-08-01

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S054000, C514S057000, C514S059000, C514S060000, C514S580000, C530S300000, C530S350000

Reexamination Certificate

active

07084112

ABSTRACT:
Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to amino-groups of biomolecules, for example polypeptides such as antibodies, enzymes, and proteins.

REFERENCES:
patent: 4220717 (1980-09-01), Kuo
patent: 4356170 (1982-10-01), Jennings et al.
patent: 5349052 (1994-09-01), Delgado et al.
patent: 5585468 (1996-12-01), Coughlin et al.
patent: 5585484 (1996-12-01), Acharya et al.
patent: 5750725 (1998-05-01), Acharya et al.
patent: 5880255 (1999-03-01), Delgado et al.
patent: 6017943 (2000-01-01), Acharya et al.
patent: 6312916 (2001-11-01), Kopetzki et al.
patent: 6342244 (2002-01-01), Zalipsky
patent: 2004/0127697 (2004-07-01), Smith
patent: 2005/0159339 (2005-07-01), Acharya et al.
patent: 0 126 043 (1984-11-01), None
patent: 0126 043 (1984-11-01), None
patent: 0157 899 (1985-10-01), None
patent: 0 157 899 (1986-10-01), None
patent: WO 94/04193 (1994-03-01), None
Boring et al. Trifuncationla Agents as a Design Strategy for Tailoring Ligand Properites: Irreversible Inhibitors of a1 Adenosine Receptors. Bioconjugate Chem. vol. 2, pp. 77-88. 1991.
Jerry E. Squires, “Artificial Blood”, Science, 295:1002, 1004-1005 (Feb. 8, 2002).
J. Milton Harris, ed.,Poly(ethylene Glycol)Chemistry: Biotechnical and Biomedical Applications: Topics in Applied Chemistry, Plenum Press (New York: 1992), pp. 1-379.
J. Milton Harris and Samuel Zalipsky, eds.,Poly(ethylene Glycol)Chemistry and Biological Applications: ACS Symposium Series 680, American Chemical Society Publishing (Washington, D.C.: 1997), p. 1-341.
Shearwater Corporation,Catalog 2001: Polyethylene Glycol and Derivatives for Biomedical Applications, Huntsville, AL 35801, (pp. 1-17).
Susan Budavari, et al., eds.,Merck Index, 11thEd., Merck & Co., Inc. (Rahway, N.J.: 1989), p. 7275, Compound No. 7268.
Porro et al., “Specific Antibodies to Diphtheria Toxin and Type 6A Pneumococcal Capsular Polysaccharide Induced By A Model of Semi-Synthetic Glycoconjugate Antigen” (1985)Mol. Immunol., 22:907-919.
Anderson et al., “Vaccines Consisting of Periodate-Cleaved Oligosaccharides from the Capsule of Haemophilus Influenze Type b Coupled to a Protein Carrier: Structural and Temporal Requirements for Priming in the Human Infant,” (1986)J. Immunol., 137:1181-1186.
Witte et al., “Enzymatic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymatic Glycopeptide Condensation and Glycosylation,” (1997)J. Am. Chem. Soc., 119:2114-2118.
Michael E. Annunziato, et al., “p-Maleimidophenyl Isocyanate: A Novel Heterobifunctional Linker for Hydroxyl to Thiol Coupling,” Bioconjugate Chem., 4:212-218 (1993).
Aldrich,Aldrich: Catalog Handbook of Fine Chemicals, (1998-1999), p. 83, Product No. 18,627-9.
Belur N. Manjula, et al., “Cys-93-ββ Succinimidophenyl Polyethylene Glycol 2600 Hemoglobin A: (Intramolecular Cross- Bridging of Hemoglobin Outside the Central Cavity,”J. Biol. Chem., 275(8):5527-5534 (2000).
Polymasc Pharmaceuticals, PLC, “Attachment of Polyethylene Glycol (PEG),” taken from www.polymasc.com/PEG/htm (Feb. 8, 2000).
Polymasc Pharmaceuticals, PLC, “Biological Optimisation and Its Importance,” taken from www.polymasc.com/PEGii.htm (Feb. 8, 2000).
Kricheldorf, et al. Chemical Abstracts, 95:25583, 1981.
Viswanathan, et al., Indian Journal of Chemistry, 20B, 308-310, 1981.

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