Activated polyers and conjugates thereof

Details Activated polyers and conjugates thereof Activated polyers and conjugates thereof

1990-08-24

1992-01-14

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564168, 435177, C07C23300, C07C23369, C12N 1102

Patent

active

050812955

ABSTRACT:
Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## in which R.sup.1 is H, C.sub.1 -C.sub.20 alkyl, phenyl, (C.sub.1 -C.sub.10 alkyl)-substituted phenyl, or phenyl-substituted C.sub.1 -C.sub.10 alkyl; R.sup.2 is C.sub.2 -C.sub.5 alkylene or (C.sub.1 -C.sub.4 alkoxy)-substituted C.sub.2 -C.sub.5 alkylene; R.sup.3 is ##STR2## R.sup.4 is H or C.sub.1 -C.sub.4 alkyl; n is at least 5; and m is zero or 1.

REFERENCES:
patent: 2714608 (1955-08-01), Matter
patent: 3789073 (1974-01-01), Narayanan et al.
patent: 4515981 (1989-05-01), Otano et al.

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