Activated peptides and conjugates

Details Activated peptides and conjugates Activated peptides and conjugates

1997-04-07

1999-11-02

MacMillan, Keith D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530324, 530325, 530326, 530345, 405403, 405402, C07K 1102, C07K 1702

Patent

active

059772999

ABSTRACT:
Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.

REFERENCES:
patent: 5066782 (1991-11-01), Montagnier et al.
patent: 5574132 (1996-11-01), Lacroix
G. A. Koppel, Bioconjugate Chem., 1, 13 (1990) published in the U.S. and entitled "Recent Advances with Monoclonal Antibody Drug Targeting for the Treatment of Human Cancer".
C.-H. Tung, et al., Bioconjugate Chem., 2, 464 (1991) published in the U.S. and entitled "Preparation of Oligonucleotide-Peptide Conjugates".
M. E. Annunziato, et al., Bioconjugate Chem., 4, 212 (1993) published in the U.S. and entitled "p-Maleimidophenyl Isocyanate: A Novel Heterobifunctional Linker for Hydroxyl to Thio Coupling".
K. Arar, et al., Tetrahedron Letters, 34, No. 50, 8087 (1993) published in Great Britain and entitled "Synthesis of Oligonucleotide-Peptide Conjugates Containing a KDEL Signal Sequence".
K. M. Wilson, et al., Journal of Immunological Methods 175, 267 (1994) published in the Netherlands and entiled "Simplified Conjugation Chemistry for Coupling Peptides Peptides to F(ab') Fragments: Autologous Red Cell Agglutination Assay for HIV-1 Antibodies".
K. Arar, et al., Bioconjugate Chem., 6, 573 (1995) published in the United States and entitled "Synthesis and Antiviral Activity of Peptide-Oligonucleotide Conjugates Prepared by Using N.alpha.-(Bromoacetyl)peptides".
R. Wetzel, R. Halualani, J. T. Stults and C. Quan. A general method for highly selective cross-linking of unprotected polypeptides via pH-controlled modification of N-terminal alpha-amino groups. Bioconjugate Chem. 1:114-122 (1990).
D. S. Jones, J. P. Hachmann, S. A. Osgood, M. S. Hayag, P. A. Barstad, G. M. Iverson and S. M. Coutts. Conjugates of double-stranded oligonucleotides with poly(ethylene glycol) and keyhole limpet hemocyanin: A model for treating systemic lupus erythematosus. Bioconjugate Chem. 5:390-399 (1994).
R. E. Galardy, L. C. Craig, J. D. Jamieson and M. P. Printz. Photoaffinity labeling of peptide hormone binding sites. J. Biol. Chem. 249:3510-3518 (1974).
C. W. T. Yeung, M. L. Moule and C. C. Yip. Photoaffinity labeling of insulin receptor with an insulin analog selectively modified at the amino terminal of the B-chain. Biochemistry 19:2196-2203 (1980).
C. C. Yip, C.W.T. Yeung and M. L. Moule. Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations. Biochemistry 19:70-76 (1980).
J. Massague, B. J. Guillette, M. P. Czech, C. J. Morgan and R. A. Bradshaw. Idendtification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling. J. Biol. Chem. 256: 9419-9424 (1981).
I. Ji and T. H. Ji. Both a and b subunits of umann choriogonadotropin photoaffinity label the hormone receptor. Proc. Natl. Acad. Sci. USA 78:5465-5469 (1981).
G. L. Johnson, V. I. MacAndrew, Jr., and P. F. Pilch. Identification of the glucagon receptor in rat liver mebranes by photoaffinity crosslinking. Proc. Natl. Acad. Sci. USA 78:875-878 (1981).
K. Ballmer-Hofer, V. Schlup, P. Burn ad M .M Burger. Isolation of in situ crosslinked ligand-receptor complexes using an anticrosslinker specific antibody. Anal. Biochem. 126: 246-250 (1982).
R. R. Goewert, M. Landt and J. M. McDonald. Calmodulin binding to rat adipocyte plasma membrance: characterization and photoaffinity crosslinking of calmodulin to binding proteins. Biochemistry 21:5310-5315 (1982).
R. L. Vandlen, K. E. Arcuri and M. A. Napier. Identification of a receptor for atrial natriuretic factor in rabbit aorta membranes by affinity cross-linking. J. Biol. Chem. 260:10889-10892 (1985).
C. L. Wood and M. S. O'Dorisio. Covalent cross-linking of vasoactive intestinal polypeptide to its receptors on intact human lymphoblasts. J. Biol. Chem. 260:1243-1247 (1985).
R. A. Nissenson, D. Karpf, T. Bambino, J. Winer, M. Canga, K. Nyiredy and C. D. Arnaud. Covalent Labeling of a high-affinity, guanyl nucleotide sensitive parathyroid hormone receptor in canine renal cortex. Biochemistry 26:1874-1878 (1987).
Narciandi et al, J. Chem. Tech. Biotechnol., vol. 66, pp. 1-6, (1996).

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