Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-06-05
2000-12-05
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C12N 916
Patent
active
061565512
ABSTRACT:
The invention relates to novel mutant SH2 domain containing protein tyrosine phosphatases wherein the phosphatase is partially or constitutively active; and whose ability to regulate biological processes are different from the wildtype protein tyrosine phosphatases. The invention also relates to methods of use of the novel mutants, for example, in in vitro assays to screen for binding partners and inhibitors of protein tyrosine phosphatases and in the treatment of protein tyrosine phosphatase mediated diseases or conditions.
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Neel Benjamin G.
O'Reilly Alana M.
Pluskey Scott
Shoelson Steven
Achutamurthy Ponnathapu
Beth Israel Deaconess Medical Center
Fronda Christian L.
Joslin Diabetes Center
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