Activated macrolactams

Details Activated macrolactams Activated macrolactams

1994-12-16

1996-04-16

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540452, C07D49816, C12P 1718

Patent

active

055083978

ABSTRACT:
Activated macrolactam compounds having the formula ##STR1## wherein n is zero or one, R.sup.101 is selected from the group consisting of methyl, ethyl, allyl, propyl and cyclopropylmethyl;
R.sup.102 is hydrogen, and R.sup.103 is selected from the group consisting of hydrogen, hydroxy and a protected hydroxy group or, taken together, R.sup.102 and R.sup.103 form a bond;
R.sup.104 and R.sup.105 are chosen such that one is hydrogen while the other is -OS(O).sub.2 F; and
R.sup.106 is selected from the group consisting of hydrogen, a protected hydroxy group, loweralkyl, alkenyl, cycloalkyl, aryl and arylalkyl,
as well as processes for making such compounds and methods for their use in the preparation of C-32-modified derivatives of ascomycin or the congeners or analogs thereof.

REFERENCES:
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 4929611 (1990-05-01), Okuhara et al.
patent: 5162334 (1992-11-01), Goulet et al.
patent: 5189042 (1993-02-01), Goulet et al.
patent: 5208228 (1993-05-01), Ok et al.
patent: 5208241 (1993-05-01), Ok et al.
patent: 5262533 (1993-11-01), Sinclair et al.
Petros, et al., J. Med. Chem. 35 2467 (1992).

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