Activated human factor VIII and method of preparation

Details Activated human factor VIII and method of preparation Activated human factor VIII and method of preparation

1995-06-06

1998-10-20

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530416, 530402, 435 681, A61K 3514

Patent

active

058247807

ABSTRACT:
A method for preparing a purified and stable activated human Factor VIII composition is disclosed. A purified and stable activated human Factor VIII composition having a specific activity of at least 100,000 units per mg protein, or a potency of at least 15,000 units per ml is also disclosed.

REFERENCES:
patent: 4386068 (1983-05-01), Mitra et al.
patent: 4387092 (1983-06-01), Liautaud et al.
patent: 4404131 (1983-09-01), Schwarz et al.
patent: 4508709 (1985-04-01), Amphlett et al.
patent: 4649132 (1987-03-01), Zimmerman et al.
patent: 4757006 (1988-07-01), Toole, Jr. et al.
patent: 4758657 (1988-07-01), Farb et al.
patent: 4769336 (1988-09-01), Zimmerman et al.
patent: 4795806 (1989-01-01), Brown et al.
patent: 4831119 (1989-05-01), Nordfang et al.
patent: 4857635 (1989-08-01), Zimmerman et al.
patent: 4868112 (1989-09-01), Toole, Jr.
patent: 4980456 (1990-12-01), Scandella et al.
patent: 4981951 (1991-01-01), Tsay
patent: 5101016 (1992-03-01), Zimmerman et al.
patent: 5149687 (1992-09-01), Scandella et al.
patent: 5278289 (1994-01-01), Johnson et al.
patent: 5484890 (1996-01-01), Johnson et al.
patent: 5576291 (1996-11-01), Curtis et al.
Journal of Biological Chemistry--vol. 269, No. 8, 25 Feb. 1994, pp. 6246-6251 "Isolation and Characterization of Thrombin-activated Human Factor VIII".
Curtis et al. Structural Studies of Human Factor VIII Activation etc. Protein Society, Jul. 1992.
Wang, Y-C.J. et al. J. of Parenteral Science & Technology, vol. 42, No. 25, pp. 52-526 (1988).
Pittman et al. A2 Domain of Human Recombinant-Derived Factor VIII etc. Blood, vol. 79, No. 2, pp. 389-397, Jan. 15, 1992.
Scandella et al. Human Factor VIII Inhibitors: Further Epitope etc., Thrombosis Haemostasis, vol. 58, Issue 1, p. 520, 1987.
Curtis et al. Characterization of a Stable Preparation of Thrombin- etc., American Society of Hematology Meeting, Anaheim, California, Dec. 8, 1992.
Tuddenham et al. The Properties of Factor VIII Coagulant Activity etc., The C.V. Mosby Company, J. Lab. Clin. Med. vol. 93, No. 1, pp. 40-43, Jan. 1979.
Weinstein et al. Analysis of Factor VIII Coagulant Antigen etc., Proc. Natl. Acad. Sci. USA, vol. 78, No. 8, pp. 5137-5141, Aug. 1981.
Vehar et al. Structure of Human Factor VIII Nature vol. 312, pp. 337-342, Nov. 22, 1984.
Fulcher et al. Localization of Human Factor VIII Inhibitor etc. Proc. Natl. Acad. Sci. USA, vol. 82, pp. 7728-7732, Nov. 1985.
Brinkhous et al. Purified Human Factor VIII Procoagulant Protein etc. Proc. Natl. Acad. Sci. USA, vol. 82, pp. 8752-8756, Dec. 1985.
Eaton et al. Construction and Characterization of an Active Factor etc. Biochemistry, vol. 25, No. 26, pp. 8343-8346, Dec. 30, 1986.
Eaton et al. Characterization of Recombinant Human Factor VIII The J. of Biological Chemistry, vol. 262, No. 7, pp. 2385-3290, Mar. 5, 1987.
Nordfang et al. FVIII Subunits: Purification and Antigenic Properties Thrombosis and Haemostasis 58 (4) 1043-1048, 1987.
Scandella et al. Epitope Mapping of Human Factor VIII Inhibitor etc. Proc. Natl. Acad. Sci. USA, vol. 85, pp. 6152-6156, Aug. 1988.
Lollar et al. Subunit Structure of Thrombin-Activated Porcine etc. Biochemistry 1989, 28, 666-674.
White et al. Factor VIII Gene and Hemophillia a Blood Reviews (1989) 3, 180-191; Blood vol. 73, No. 1, pp. 1-12, Jan. 1989.
Bihoreau et al. Isolation and Characterization of Differenct etc. Eur. J. Biochem. 185, 111-118 (1989) Feb.
Scandella et al. Localization of Epitopes for Human Factor VIII etc. Blood, vol. 74, No. 5, Oct. 1989, pp. 1618-1626.
Tuddenham, Factor VIII and Haemophilia A Bailliere's Clinical Haematology, vol. 2, No. 4, Oct. 1989, pp. 849-877.
Kaufman, Genetic Engineering of Factor VIII Nature vol. 342, 9 Nov. 1989, pp. 207-208.
Nordfang, Coagulation Factor VIII European J. of Heamatology, Supplementum No. 49, vol. 43, 1989.
Lollar et al. PH-Dependent Denaturation of Thrombin-Activated etc. The J. of Biological Chemistry, vol. 265, No. 3, pp. 1688-1692, Jan. 25, 1990.
Foster et al. Synthetic Factor VIII Peptides with Amino Acid etc. Blood, vol. 75, No. 10, pp. 1999-2004, May 15, 1990.
Kemball-Cook et al. Factor VIII Heavy Chain Polypeptides in Plasma etc. British Journal of Haematology, 1990, 76, 80-87.
Foster et al. A Synthetic Factor VIII Peptide of Eight Amino Acid etc. Thrombosis and Haemostasis, 63 (3) 403-406 (1990).
Krishnan et al. Thrombin Cleavage Analysis of a Novel etc. Eur. J. Biochem. 195, pp. 637-644 (Received 1990) Feb. 1991.
Ingerslev et al. Clinical Experience with Hemofil M in a Hemophillia etc. Ann. Hematol (1991) 63: 52-154.
Fay et al. Human Factor VIIIA Subunit Structure Reconstitution etc. The J. of Biological Chemistry vol. 266, No. 14, pp. 8957-8962, May 15, 1991.
Lollar et al. Structural Basis for the Decreased Procoagulant etc. The J. of Biological Chemistry vol. 266, No. 19, pp. 12481-12486, Jul. 5, 1991.
Fay et al. Characterization of the Interaction Between the A2 Subunit etc. The J. of Biological Chemistry vol. 267, No. 19, pp. 13246-13250, Jul. 5, 1992.
Foster et al. Factor VIII Structure and Function Blood Reviews (1989) 3, 180-191; 1989 Longman Group UK Ltd.

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