Actinoplanes transformation process anti-hypertensive compound a

Details Actinoplanes transformation process anti-hypertensive compound a Actinoplanes transformation process anti-hypertensive compound a

1992-04-23

1993-05-25

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 3141, C07D40306

Patent

active

052141535

ABSTRACT:
Fermentation of the microorganism Actinoplanes sp. MA6559 (ATCC 53771) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields a new compound, hydroxylated in the 2-butyl group, which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

REFERENCES:
Ralph A. Stearns et al., Drug Metabolism and Disposition, vol. 20, No. 2, pp. 281-287 (1992).

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