Actinobacillus pleuropneumoniae subunit vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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4242361, 4241841, 435243, 435261, 530350, A61K 39102, A61K 3900, A61K 3902, C12N 100

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active

056480814

ABSTRACT:
The present invention is concerned with vaccines effective in protecting pigs against porcine pleuropneumonia. Said vaccines comprising a hemolysin and/or macrophage toxin and a 42 kD OMP preparation derived from Actinobacillus pleuropneumoniae (App) cells induce a complete and heterologous protection against App infection.

REFERENCES:
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Woodward et al. Journal of Immunological Methods 78:142-153 1985, Detection of Monoclonal Antibodies Specific for Carbohydrate Epitopes Using Periodate Oxidation.
Devenisk et al. Infect & Imm 1990: 3829-3832 vol. 58 (1).
Devenisk et al. Inf & Immun 57:3210-3213 Oct. 1989 (2).
Rycroft et al. Veterinary Microbiology 15: 303-314, 1987.
Rycroft et al Journal of General Microbiology Mar. 29, 1991 137: 561-568.
Mac Innes et al. Infect & Immunity 55: 1626-1634 1987.
J. I. MacInnes et al., "Analysis of Major Antigens of Haemophilus Pleuropneumoniae and Related Organisms", Biological Abstracts, vol. 84, 1987, Abstract No. 52672, Infection Immunology, vol. 55., No. 7, 1987, pp. 1626-1634.

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