Actin related cytoskeletal protein “LACS”

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C530S356000

Reexamination Certificate

active

07345158

ABSTRACT:
The present invention provides the novel L-NAME-related actin cytoskeletal protein (LACS) and genes encoding the protein.

REFERENCES:
patent: 2002/0110804 (2002-08-01), Stanton
patent: WO01/55326 (2001-08-01), None
patent: WO 01/74901 (2001-10-01), None
Brower et al. (1995) Genetic analysis of the fimbrin-actin binding interaction inSaccharomyces cerevisiae. Genetics. vol. 140, No. 1, pp. 91-101.
Karlin et al. (1993) Applications and statistics for multiple high-scoring segments in molecular sequences. Proc Natl Acad Sci U S A. vol. 90, No. 12, pp. 5873-5877.
Cros et al. (2001) Analysis of altered gene expression in rat soleus muscle atrophied by disuse. J. Cell. Biochem. vol. 83, No. 3, pp. 508-519.
Lehrer-Graiwer, Joshua E., et al.; “Nitric oxide mediated induction of cytochrome c oxidase mRNA and protein in a mouse macrophage cell line;”Neuroscience Letters; Jul. 14, 2000; pp. 107-110; 288:2.
Kataoka, Chu, et al.; “Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockage of nitric oxide synthesis in rats;” Hypertension; 2002; pp. 245-250; 37:245.
Lehrer-Graiwer, Joshua E., et al.; “Nitric oxide mediated induction of cytochrome c oxidase mRNA and protein in a mouse macrophage cell line;”Neuroscience Letters; Jul. 14, 2000; pp. 107-110; 288:2.
Shujiro, Inoue, et al.; “Identification of a novel gene involved in the pathogenesis of cardiac hypertrophy in rats;”Japanese Circulation Journal; Mar. 31, 2002; p. 765; 66: (Supplement 1).
Takaori, Kazuo, et al.; “Inhibition of nitric oxide synthase causes cardiac phenotypic modulating In rat;”European Journal of Pharmacology; Mar. 12, 1997; pp. 59-62: 322:1.
Kataoka, Chu, et al.; “Important Role of Rho-kinase in the Pathogenesis of Cardiovascular Inflammation and Remodeling Induced by Long-Term Blockade of Nitric Oxide Synthesis in Rats;”Hypertension; Feb. 2002; pp. 245-250; 39:2.

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