Acridinium ester labels having hydrophilic modifiers

Details Acridinium ester labels having hydrophilic modifiers Acridinium ester labels having hydrophilic modifiers

2001-07-03

2003-12-16

Dentz, Bernard (Department: 1625)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S006120, C435S007100, C435S007500, C530S391500, C536S018700, C544S257000, C544S268000, C546S104000

Reexamination Certificate

active

06664043

ABSTRACT:

FIELD OF THE INVENTION
The present invention is useful in bioanalytical applications and is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such labels; and to processes for performing bioanalytical assays for target analytes which use such labels.
BACKGROUND OF THE INVENTION
Acridinium esters are extremely useful chemiluminescent labels that have been extensively used in the field of immunoassays as well as nucleic acid assays. Each of the following patent documents is both (a) incorporated herein by reference in its respective entirety; and (b) directed to varying aspects of bioanalytical applications of acridinium ester compounds. EP0263657; U.S. Pat. No. 4,745,181; EP0353971; EP0361817; U.S. Pat. No. 4,918,192; U.S. Pat. No. 5,110,932; U.S. Pat. No. 5,227,489; U.S. Pat. No. 5,241,070; EP0617288; WO9421823; U.S. Pat. No. 5,395,752; EP0661270; U.S. Pat. No. 5,449,556; WO9527702; U.S. Pat. No. 5,538,901; U.S. Pat. No. 5,595,875; EP0754178; U.S. Pat. No. 5,656,426; U.S. Pat. No. 5,656,500; U.S. Pat. No. 5,663,074; U.S. Pat. No. 5,702,887; WO9854574; U.S. Pat. No. 5,879,894; WO9911813; WO0009487; EP0982298; EP0988551; WO0031543; EP1009852; U.S. Pat. No. 6,080,591; EP1049933; U.S. Pat. No. 6,165,800; WO0109372 & EP1104405. Certain particular detectable chemiluminescent acridinium ester labels lacking hydrophilic modifiers are well-known in the art—e.g., 2′,6′-dimethyl-4′-[N-succinimidyloxycarbonyl]phenyl-10-methyl-9-acridine carboxylate and 2′,6′-dimethyl-4′-[N-succinimidyloxycarbonyl]phenyl-10-sulfopropyl-9-acridine carboxylate {each label being hereinafter referred to as, respectively, “DMAE-NHS” and “NSP-DMAE-NHS”}—and are being commercialized for immunoassay instrument systems available from Bayer Corporation, Business Group Diagnostics, 511 Benedict Avenue, Tarrytown, N.Y. 10591-5097. For the reader's convenience, the structure of each of these compounds is depicted below.


REFERENCES:
patent: 5656426 (1997-08-01), Law et al.

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