Acridinium compounds as chemiluminogenic label

Details Acridinium compounds as chemiluminogenic label Acridinium compounds as chemiluminogenic label

1991-06-24

1996-05-28

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

436543, 436544, 436805, 5303915, 530402, 530404, 530405, 546102, 546103, 546104, G01N 33536, C07K 1618

Patent

active

055211038

ABSTRACT:
New acridinium compounds are provided which comply with formula 1, wherein
A is a divalent organic moiety, such as an alkylene chain,
X is a group which can be transformed together with C-9 of the acridine into a dioxetane by reaction with hydrogen peroxide, such as an aryloxy group,
Y is a counter ion, and
Z is a functional group, such as a carboxyl derivative.
These acridinium compounds are useful as chemiluminogenic labels for both heterogeneous and homogeneous immunoassays.

REFERENCES:
patent: 2645594 (1953-07-01), Tabern et al.
patent: 3431264 (1969-03-01), Sheehan et al.
patent: 3539574 (1970-11-01), Sheehan et al.
patent: 3615416 (1971-10-01), Fox
patent: 4745181 (1988-05-01), Law
Abbott Laboratories "Acridinium Salts . . . " CA111:97109p (1989) JP-63112564 May 1988.
Sargeut "Carbinolamines derived from N-9 . . . Acridive" CA 52:383g (1958).
Weeks et al., Acridinium Esters as High-Specific-Activity Labels in Immunoassay, Clin. Chem. 29:1474-1479 (1983).
Patel, et al., Homogeneous Immunoassay Based On Chemiluminescence Energy Transfer, Clinical Chemistry, (1983).
Forster, Experimentelle und theoretische Untersuchung des zwischenmolekularen Ubergangs von Klektronenanregungsenergie, Z. Naturforschg. 4a 321-327 (1949).
Forster, Zwischenmolekulare Energiewanderung und Fluoreszenz Annalen der Physik. G. Folge. Band 2 (1948).

Affiliated with

Also associated with

Rating

Acridinium compounds as chemiluminogenic label does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acridinium compounds as chemiluminogenic label, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acridinium compounds as chemiluminogenic label will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-786163