Acridine-intercalator based hypoxia selective cytotoxins

Details Acridine-intercalator based hypoxia selective cytotoxins Acridine-intercalator based hypoxia selective cytotoxins

1991-02-01

1994-03-15

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514297, C07D23391

Patent

active

052947157

ABSTRACT:
Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.

REFERENCES:
patent: 4954515 (1990-09-01), Suto
patent: 5073639 (1991-12-01), Suto
Denny et al. Chem. Abstr. vol. 116 Entry 190298n (1992).
Panicucci et al. Int. J. Radiation Oncology Biol. Phys. vol. 16 pp. 1039-1043 (1989).
Roberts, Int. J. Radiation, Biol. vol. 51 641-54 (1987).
Roberts, Radiation Res. vol. 123 pp. 153-164 (1990).
Denny et al. Int. J. Radiation Oncology Biol. Phys vol. 22 pp. 553-556.
Alper, T., et al Nature 178:978-979 (1956).
Dische, S., et al Br. J. Radiol., 56:251-255 (1983).
Churchill-Davidson, I., et al, Lancet 1:1091-1095 (1955).
Bush, R. S., et al., Br. J. Cancer 37 (Suppl. III):302-306 (1978).
McNally, N. J., Int. J. Radiat. Oncol. Biol. Phys. 8:593-598 (1982).
Overgaard J., et al., Progress in Radio-Oncology III, Proceedings of the 3rd International Meeting on Progress in Radio-Oncology, Mar. 1985, 137-147, J.C.R.O., Vienna, (1987).
Coleman, C. N., et al., Int. J. Radiat. Oncol. Biol. Phys. 10:1749-1753 (1984).
Roberts, J. T., et al., Int. J. Radiat. Oncol. Biol. Phys. 10:1755-1758 (1984).
Saunders, M. I. et al., Int. J. Radiat. Oncol. Biol. Phys. 10:1759-1763 (1984).
Adams, G. E., et al., Br. J. Cancer 49:571-577 (1984).
Stratford, I. J., et al, Int. J. Radiat. Biol. 55:411-422 (1989).
Nias, A. H. W., Int. J. Radiat Biol. 48:297-314 (1985).
Ahmed, I., et al., Int. J. Radiat. Oncol. Biol. Phys. 12:1079-1081 (1986).
Sieman, D. W., Int. J. Radiat. Oncol. Biol. Phys. 10:1585-1594 (1984).
Brown, J., Int. J. Radiat. Oncol. Biol. Phys. 16:987-993 (1984).
Stratford, M. R. L., et al., Int. J. Radiat, Oncol. Biol. Phys. 16:1007-1010 (1989).
Chibber, R., et al. Int. J. Radiat. Oncol. Biol. Phys. 10:1213-1215 (1984).
Teicher, B. A., et al., Int. J. Radiat Oncol. Biol. Phys. 11:937-941 (1985).
Skov, K. et al., Int. J. Radiat. Biol. 52:289-297 (1987).
Chan, P. K. L., et al. Int. J. Radiat. Oncol. Biol. Phys. 12:1059-1062 (1986).
Chan, P. K. L., et al., Int. J. Radiat. Biol., 52:49-55 (1987).
Butler, J., et al., Radiation Research 102:1-13 (1985).
Panicucci, R., et al., Int. J. Radiat. Oncol. Biol. Phys. 16:1039-1043 (1989).
Wilson, W. R., et al., Br. J. Cancer 49:215-223 (1984).
Roberts, P. B., et al., Int. J. Radiat. Biol. 51:641-654 (1987).
Roberts, P. B., et al., Radiation Research 123-153-164 (1990).
Wilson, W. R., et al., Int. J. Radiat. Oncol. Biol. Phys. 12:1235-1238 (1983).
Adams, G. E., et al., Chemical Abstracts 102:6489n (1985).
Stratford, I. J., et al., Int. J. Radiat. Oncol. Biol. Phys. 16:973-976 (1989).

Affiliated with

Also associated with

Rating

Acridine-intercalator based hypoxia selective cytotoxins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acridine-intercalator based hypoxia selective cytotoxins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acridine-intercalator based hypoxia selective cytotoxins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1536981