Acoustically reflective liposomes and methods to make and use sa

Details Acoustically reflective liposomes and methods to make and use sa Acoustically reflective liposomes and methods to make and use sa

1995-10-11

1997-03-18

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 121, 4284022, 436829, A61K 9127

Patent

active

056120575

ABSTRACT:
This invention relates to tissue specific acoustically reflective oligolamellar liposomes containing internally separated bilayers and methods to make and to use the same, alone as a perfusion ultrasonic contrast agent or conjugated to a ligand for tissue-specific ultrasonic image enhancement.

REFERENCES:
patent: 4647447 (1987-03-01), Gries et al.
patent: 4857319 (1989-08-01), Crowe
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4920016 (1990-04-01), Allen
patent: 5116615 (1992-05-01), Gokcen et al.
patent: 5123414 (1992-06-01), Unger
patent: 5262168 (1993-11-01), Lenk
Szoka, et al., "Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-Evaporation", Proc. Natl. Acad. Sci. 75:9 4194-9418 (Sep. 1978).
Abstract, American College of Cardiology, No. 42644, published Feb. 26, 1992.

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