Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2000-02-11
2002-06-04
Jaworski, Francis J. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S458000
Reexamination Certificate
active
06398732
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to ultrasound imaging systems and, more particularly, to a method for detecting the location of boundaries between tissue regions and blood-filled regions within an area of anatomy being imaged.
BACKGROUND OF THE INVENTION
In the presentation of ultrasound images of anatomical features, there is a continuing need to improve the ability to precisely identify tissue/blood boundaries. The availability of images that precisely identify such boundaries enable an examining physician to better discern physical abnormalities. Recently, to improve the contrast between blood-filled regions and tissue regions, ultrasound contrast agents have been used. Such contrast agents are substances which strongly interact with ultrasonic waves, returning echoes which may be clearly distinguished from those returned by both blood and tissue.
Certain contrast agents consist of microbubbles which present a significant acoustic impedance mismatch and a non-linear behavior in certain acoustic fields. Such non-linear behavior is readily detectable through special ultrasonic processing. One type of microbubble contrast agent comprises microbubbles of an inert gas that are coated with a thin biodegradable coating or shell. Such microbubbles are infused into the body and survive passage through the pulmonary system and circulate throughout the vascular system.
The non-linear response of microbubble contrast agents, as contrasted to a relatively linear response from tissue is illustrated in FIG.
1
. There, the return from a contrast agent with increasing levels of acoustic transmit power is plotted versus echo magnitude. As can there be seen, the contrast agent echo response exhibits an exponential relationship whereas the response from tissue is approximately linear. Accordingly, at higher acoustic transmit power levels, the contrast agent echo response exhibits a larger difference from the tissue echo response than at lower acoustic transmit power levels.
U.S. Pat. No. 5,577,505 to Brock-Fisher et al., assigned to the same assignee as this Application, describes a method for enhancing the detection of echo returns from microbubbles in circulation relative to tissue. Brock-Fisher et al. achieve increased sensitivity to non-linear responses from the microbubbles by transmitting a first ultrasound signal at a first power level into a region of interest (ROI) to be imaged. The echo responses gathered from that ultrasound signal are stored, and a second ultrasound signal is applied, at a second power level and the ultrasound echo responses stored.
The ultrasound responses are gain compensated and further processed to subtract one from the other so as to remove most of the linear response values from the exponential echo response signal. What remains corresponds to the exponential response portion of the microbubble contrast agent backscatter. The determined difference values are color-coded and added back into the original image in the spatial areas from which the echo signals were generated, enabling better identification of the blood-filled regions carrying the contrast agent.
Notwithstanding the ability to better image the contrast agent in areas of blood circulation, there still is a need to better identify boundaries between tissue and contrast agent-containing regions of an ultrasound image.
SUMMARY OF THE INVENTION
The method of the invention controls an ultrasound system to identify a boundary between a tissue region and a blood-filled region that lies within an ROI. A first embodiment of the method initially administers a contrast agent to the region of interest and then transmits a first ultrasound beam at a first power level into the ROI. signal returns from the first beam are processed and stored as first digital signal values. Thereafter, a second ultrasound beam is transmitted at a second power level into the ROI and the signal returns therefrom are processed to derive second digital signal values which may then be used to identify a boundary between a blood filled cavity and tissue.
It has been determined that, under certain circumstances, a phase change of echo returns occurs at the boundary between tissue and blood-containing contrast agent. Detection of the phase change enables precise identification of the boundary, based upon the time segment in which the phase change is detected. Accordingly, time segment values of the first and second stored digital values are phase-compared to enable determination, by detection of a phase change, of a boundary location between the tissue region and the blood-filled region.
REFERENCES:
patent: 5148809 (1992-09-01), Biegeleisen-Knight et al.
patent: 5195521 (1993-03-01), Melton, Jr. et al.
patent: 5533510 (1996-07-01), Koch, III et al.
patent: 5538003 (1996-07-01), Gadonnieux et al.
patent: 5577505 (1996-11-01), Brock-Fisher et al.
patent: 5662113 (1997-09-01), Liu
patent: 6030344 (2000-02-01), Guracar et al.
patent: 6106465 (2000-08-01), Napolitano et al.
Brock-Fisher George A
Prater David M
Jaworski Francis J.
Koninklijke Philips Electronics , N.V.
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