Aconitine compounds and analgesic/anti-inflammatory agent contai

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 39, C07D22122, A61K 31435

Patent

active

055146848

ABSTRACT:
Novel aconitine compounds of the formula ##STR1## wherein the symbols are as defined in the description, as well as analgesic/anti-inflammatory agent containing them or salts thereof as active ingredient.

REFERENCES:
patent: 5290784 (1994-03-01), Qu et al.
Murayama et al, Chem. Abstract 112:21188p (1990) for JP 01-143859 (Jun. 6, 1989).
The Merck Index, 11th ed (1989), Merck and Co. Inc., p. 18.
Takayama et al, Chem. Pharm. Bull, 30(1), (1982), pp. 386-389.
Chemical and Pharmaceutical Bulletin, vol. 39, No. 2, Feb. 1991, Tokyo JP, pp. 379-383; Mori et al: "Studies on the Constitutents of Aconitum Species. XII. Syntheses of Jesaconitine Derivatives and Their Analgesic and Toxic Activities".
Chemical Abstracts, vol. 116, No. 11, 16 Mar. 1992, Columbus, OH; Abstract No. 106574, p. 808; & JP-A-03 223 255 (Sanwa Seeiyaku Co. Ltd.) 2 Oct. 1991.
Grant & Hackh's Chemical Dictionary, 5th ed (1987), Roger Grant et al., p. 22.

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