Aconitase

Details Aconitase Aconitase

2007-02-27

2007-02-27

Campell, Bruce R. (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S004000, C435S005000, C435S006120, C435S069100, C435S069700, C435S252300, C435S320100, C530S300000, C530S350000, C536S023400, C536S063000, C514S04400A, C514S459000, C424S190100, C424S260100

Reexamination Certificate

active

10441919

ABSTRACT:
A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria and inhibitors of production or activity of this protein in combination with propionic acid mitigate the virulence of these bacteria.

REFERENCES:
patent: 6551795 (2003-04-01), Rubenfield et al.
Rudinger et al, in “Peptide Hormones”, edited by Parsons, J.A., University Park Press, Jun. 1976, p. 6.
Burgess et al., The Journal of Cell Biology, 111:2129-2138, 1990).
Database: PIR—80, Accession No. A83547.
Altschul et al., Nucleic Acids Research (1997) 25(17):3389-3402.
BLAST search referenced in Altschul et al., Nucleic Acids Research (1997) 25(17):3389-3402.
Duplantier et al., Bioorganic and Medicinal Chemistry Letters (2001) 11:2593-2596.
International Search Report for PCT/US04/24051, mailed on Jan. 18, 2006, 4 pages.
Yoon et al., Developmental Cell (2002) 3:593-603.

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