Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-02-06
1992-09-01
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530345, 5303919, 530404, 530405, 530406, 530408, 530409, 530410, 424 858, 424 8591, 435 71, 435174, 435188, 525 511, 549 60, 549 62, 562512, 210635, C07K 1706, A61K 3944, A61K 4748
Patent
active
051440113
ABSTRACT:
A method for controlling the release of durgs or other passenger molecules form carrier conjugates, and a class of conjugates that releases drugs when ingested by a cell or subjected to acidic conditions, are disclosed. These conjugates contain a passenger molecule which is attached to a spacer molecule through an acidic bonding group, such as carboxyl, that is in a "cis" configuration with another acidic group, and a carrier molecule that is bonded to the spacer molecule at another site. When subjected to a mild increase in acidity, such as occurs within a lysosome of a cell, the drug or other passenger molecule is hydrolyzed from the the conjugate and released in unmodified, active form.
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Ryser Hugues J.-P.
Shen Wei C.
Boston University
Kim Kay K.
Nucker Christine M.
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