Acidic formulations of t-PA

Details Acidic formulations of t-PA Acidic formulations of t-PA

1990-05-21

1992-05-12

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514822, 530324, 435212, A61K 37547, C12N 950

Patent

active

051126095

ABSTRACT:
An aqueous parenteral solution of tissue-plasminogen activator, in which the pH is from 2 to 5.

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patent: 4968617 (1990-11-01), Johnston et al.
Rote Liste, 1985*.
J. Biol. Chem., 254(6) pp. 1998-2003, 1979, Binder, et al.
Rijken et al. J. Biol. Chem., 256(13), 7035-7041, 1981.
Yukiyoshi Hamaguchi, Mie Medical Journal, vol. XXXIII, No. 1, 1983, Partial Purification and Properties of Tissue-Type Plasminogen Activator From Nasal and Maxillary Mucosae.
Rijken, et al., The Journal of Biological Chemistry, vol. 256, No. 13, Jul. 10, 1981, pp. 7035-7041, Purification and Characterization of the Plasminogen Activator Secreted by Human Melanoma Cells in Culture.
Binder, et al., The Journal of Biological Chemistry, vol. 254, No. 6, Mar. 25, 1979, pp. 1998-2003, Purification and Characterization of Human Vascular Plasminogen Activator Derived from Blood Vessel Perfusates.
Welmar, et al., The Lancet, Nov. 7, 1981, Preliminary Communication, pp. 1018-1020, Specific Lysis of an Iliofemoral Thrombus by Administration of Extrinsic (Tissue-Type) Plasminogen Activator.
Abstract-Preparative Biochemistry, 12(4), pp. 297-305, (1982).
Remington's Pharmaceutical Sciences, Fifteenth Edition (1975), pp. 273-274.
Dano et al., Biochimica et Biophysica Acta 613(1980) 542-555.
Camiolo et al., cited in Biological Abstracts 76(2):883 Ref. No. 8252 1982.
Wilson et al., Chem. Abstracts, vol. 92:144679a, 1980.
Vetterlein et al., Chem. Abstracts, vol. 90:135631k 1979.
Hamaguchi, Mie Medical Journal, vol. XXXIII, No. 1, 1983, pp. 57 and 66 to 67, Partial Purification and Properties of Tissue-Type Plaminogen Activator from Nasal and Maxillary Mucosae.

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