Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1987-04-01
1989-04-11
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C07C 59265
Patent
active
048208701
ABSTRACT:
The invention provides a novel acidic alkali citrate having the formula K.sub.6 Na.sub.6 H.sub.3 (C.sub.6 0.sub.7 H.sub.5).sub.5 . 2-4 H.sub.2 O made by dissolving either
(a) trisodium citrate.times.2 H.sub.2 O, tripotassium citrate.times.1 H.sub.2 O, and citric acid in a mole ratio of 2:2:1 in 3 to 5 times the quantity by weight of boiling demineralized water, based on the weight of the citric acid and maintaining the solution at a temperature not lower than 60.degree. C.; or
(b) citric acid at 90.degree. C. while stirring in .01 to 1 times its weight of demineralized water and then adding sodium carbonate and potassium carbonate to give a mole ratio of 3:3:5 of sodium carbonate: potassium carbonate:citric acid,
and quick drying the homogeneous solution obtained. Therapeutic agents for the treatment of urolithiasis and removal, or preventing recurrence, of urine stones comprising said acidic alkali citrate are provided.
REFERENCES:
patent: 3658969 (1972-04-01), Renie
Hackh's Chemical Dictionary, 4th Ed. (1969) at page 161, McGraw-Hill, Publ.
Carcasona-Beltran Alfonso
Gorler Klaus
Madaus Rolf
Stumpf Werner
Dr. Madaus & Co.
Killos Paul J.
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